![]() ![]() ![]() No adverse effects were observed during the experimental period. The time to loss of righting reflex was 14.8 ± 6.5 and 12.5 ± 7.4 minutes and sedation scores were 6 (4–8) and 7 (6–8) for IM and IN routes respectively, with no difference between treatments. The only statistically significant change was for fR, which was significantly lower after sedation for both routes. Measured variables remained within normal physiologic ranges for all rabbits. ![]() Heart rate (HR), respiratory rate (fR) and temperature (T) were recorded prior to treatment administration and after loss of the righting reflex. The righting reflex was assessed, and sedation was scored. Sufentanil (0.5 μg kg⁻¹) and midazolam (2 mg kg⁻¹) were administered to rabbits by either IM or IN route. Prospective, randomized, crossover, experimental study.Ī total of 11 adult New Zealand White rabbits. To evaluate the sedative effects of a combination of sufentanil and midazolam administered intramuscularly (IM) or intranasally (IN) prior to induction of anesthesia with propofol in New Zealand White rabbits. ![]()
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